Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
RAS Proto-oncogene (RAS)
- Target
- RAS
- Molecular classification
- Small GTPase, Proto-oncogene, Oncogene (mutated)
01
Overview
The RAS proto-oncogene family (HRAS, KRAS, NRAS) encodes small GTPase proteins that function as molecular switches in intracellular signaling pathways, regulating cell proliferation, differentiation, and survival. Mutations in RAS genes, particularly at codons 12, 13, or 61, lead to constitutive activation of the RAS protein, driving uncontrolled cell growth and contributing to the development of various cancers. Activated RAS triggers downstream pathways like MAPK/ERK and PI3K/AKT, modulating gene expression and cellular behavior.
- Other names
- HRASKRASNRAS
02
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalRegulation of cell cycle
03
Disease associations
CancerPancreatic cancerLung cancerColon cancerThyroid cancer
04
Safety considerations
Drug resistanceOff-target effectsLimited efficacy due to pathway redundancy
05
Biomarkers
KRAS mutations (codons 12, 13, 61)HRAS mutations (codons 12, 13, 61)NRAS mutations (codons 12, 13, 61)
Beyond the preview
Go deeper on RAS Proto-oncogene (RAS).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RAS Proto-oncogene (RAS).