Ras-related and estrogen-regulated growth inhibitor (RERG)

Ras-related and estrogen-regulated growth inhibitor (RERG) is a protein encoded by the RERG gene in humans. It is a member of the Ras superfamily of small GTPases, characterized by GDP/GTP-binding and intrinsic GTPase activity, with higher affinity for GDP than GTP[1][2][8]. RERG acts as a negative regulator of cell proliferation and tumor formation; overexpression in cell lines reduces proliferation rate, colony formation, and tumorigenic potential[1][2][3][8]. Inactivation or loss of RERG expression is associated with breast cancer and may act as a tumor suppressor, particularly in estrogen-regulated contexts[2][3][5]. This protein likely participates in signal transduction pathways that control cell growth in response to estrogen stimulation.

Other names

RAS like estrogen regulated growth inhibitorRas-like estrogen-regulated growth inhibitorRERG