Ras-related protein Rab-10 (RAB10)

Ras-related protein Rab-10 (RAB10) is a member of the RAS superfamily of small GTPases, predominantly involved in the regulation of intracellular membrane trafficking processes, including exocytosis, endocytosis, and biosynthetic transport of proteins from the Golgi to the plasma membrane[1][5]. RAB10 regulates the trafficking of various proteins (e.g., GLUT4, TLR4) and is involved in neuronal development, cell polarity, endoplasmic reticulum dynamics, ciliogenesis, and phagosome maturation[1][3][5]. Dysregulation or overexpression of RAB10 is implicated in tumor proliferation, invasion, immune cell infiltration in tumors, and certain neurological disorders. It functions by cycling between active GTP-bound and inactive GDP-bound states to recruit effectors that mediate vesicle formation, movement, and fusion in cells[1][5][3]. If more structurally-defined drug interactions or targeted inhibitors are discovered in the future, this molecule may emerge as a therapeutic target, particularly in cancer or neurodegenerative disease contexts. Currently, its status is mainly as a functional molecular target and emerging biomarker, not as a direct drug target.

Other names

RAB10ras-related GTP-binding proteinGTP-binding protein RAB10Ras-related protein Rab-10RAB10, member RAS oncogene family

For indirect targeting via LRRK2, mechanism includes inhibition of RAB10 phosphorylation. No direct mechanism for small molecule inhibitors or approved biologicals is validated[3].