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Target intelligence / Profile preview
Ras-related protein Rab-11A (RAB11A)
- Target
- RAB11A
- Molecular classification
- Small GTPase, Rab family GTPase
01
Overview
Ras-related protein Rab-11A (RAB11A) is a small GTPase that plays a key role in regulating intracellular membrane trafficking, particularly in endocytic recycling and vesicle transport. It acts as a molecular switch, cycling between inactive GDP-bound and active GTP-bound states, influencing various cellular processes including immune response, epithelial polarity, cilia growth, and cancer cell behavior. RAB11A interacts with several proteins including FIPs, MYO5B, Dynein, ARF4 and WDR44 and its activity is linked to WNT and PI3K/AKT signaling pathways.
- Other names
- RAB11Ypt31pMGC119379ras-related protein Rab-11A
02
Biological functions
Endocytic recyclingVesicle traffickingCytokinesisIntracellular membrane traffickingInnate immune receptor traffickingProtein recyclingCiliogenesis
03
Disease associations
Cancer cell proliferationCancer cell motilityEsophageal cancerHepatocellular carcinomaVascular leakage (related to endothelial barrier dysfunction)
04
Safety considerations
Potential disruption of normal cellular trafficking processesVascular leakage if inhibited
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