Ras-related protein Rab-11B (RAB11B)

Ras-related protein Rab-11B (RAB11B) is a member of the Rab subfamily of the Ras superfamily of small GTPases, involved in regulating intracellular membrane trafficking including vesicle budding, movement, tethering, and fusion[1][3][6]. RAB11B primarily functions in the recycling of proteins from endosomes to the plasma membrane and is distinguished from the closely related RAB11A by its tissue expression (most abundant in brain, heart, and testes) and unique vesicular compartment localization[1][3]. It regulates exocytosis, endocytosis, and the degradation and recycling of multiple membrane channels and transporters, such as CFTR and L-type calcium channels[2][3]. In gut epithelial cells, RAB11B plays a critical role in maintaining mitochondrial structure and function; its absence leads to impaired mitochondrial integrity and activity[5]. Mutations or dysfunction in RAB11B are associated with rare neurodevelopmental disorders and cellular physiological defects[3][5].

Other names

RAB11BYPT3H-YPT3GTP-binding protein YPT3Ras-related protein Rab-11B

Small GTPase cycling (GDP/GTP-bound switching) regulating recruitment of effectors for vesicle formation, tethering, and fusion Modulation of membrane protein degradation and recycling (e.g., Ca_v_1.2 L-type Ca^2+ channel, CFTR, ENaC) Regulation of mitochondrial protein targeting and integrity in epithelial cells