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Target intelligence / Profile preview
Ras-related protein Rab-1A (RAB1A)
- Target
- RAB1A
- Molecular classification
- Small GTPase, Enzyme, Member of the Ras superfamily of small GTPases
01
Overview
Ras-related protein Rab-1A is a small GTPase that cycles between an active GTP-bound form and an inactive GDP-bound form, acting as a critical regulator of vesicle formation, movement, tethering, and fusion in intracellular membrane trafficking. It mediates transport of proteins from the endoplasmic reticulum to the Golgi apparatus and beyond, regulates secretion of key molecules like IL-8 and growth hormone, and influences Golgi morphology, cell adhesion, migration, autophagy, and host defense mechanisms against pathogens. The gene is linked with multiple cellular pathways, and dysregulation of RAB1A is associated with various human diseases, particularly several cancer types[1][4][9].
- Other names
- RAB1ARAB1YPT1member RAS oncogene family
02
Biological functions
Regulation of vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus and to the cell surfaceControl of intracellular membrane traffickingModulation of Golgi morphologyRegulation of secretion of interleukin-8 (IL-8) and growth hormoneRegulation of cell adhesion and migrationRole in autophagosome assembly and cellular defense against pathogenic bacteriaInvolvement in microtubule-dependent protein transport via early endosomesAnterograde melanosome transport
03
Disease associations
Cancer (correlation with various cancers, e.g. glioma, esophageal neuroendocrine tumor, associations in tissue expression studies)[1][5][8]Choroideremia[1]Roles in cellular proliferation, invasion, and epithelial-mesenchymal transition (noted in glioma)[8]
04
Biomarkers
Overexpression or altered expression in certain cancers (e.g., glioma, as seen in gene expression/cancer association studies)[5]
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