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Target intelligence / Profile preview
Ras-related protein Rab-21 (RAB21)
- Target
- RAB21
- Molecular classification
- Small GTPase, Enzyme, Ras family, Rab subfamily
01
Overview
Ras-related protein Rab-21 (RAB21) is a member of the Rab family of small GTPases within the Ras superfamily, involved in the regulation of intracellular membrane trafficking[1][4]. It is essential for the endocytic trafficking and recycling of integrins, affecting cell adhesion, migration, and cytokinesis, and has been implicated in processes such as autophagy, endosomal sorting, and receptor turnover, including that of the epidermal growth factor receptor and Toll-like receptor 4[1][2][4]. RAB21 dysregulation is associated with poor prognosis in glioma and other cancers, and may play roles in neurodevelopment and immune response by orchestrating specific endosomal sorting pathways[1][2][4]. No specific drugs directly targeting RAB21 are approved; research suggests its disease associations and cellular roles make it a potential therapeutic target and biomarker in cancer and possibly neurodegenerative disease[1][4].
- Other names
- RAB21KIAA0118GTP-binding protein RAB21member RAS oncogene family
02
Mechanism of action
Not established for therapeutic drugs; theoretically, modulation of integrin trafficking, endosomal recycling, and autophagy are mechanisms regulated by RAB21 itself
03
Biological functions
Regulation of membrane traffickingEndosomal sortingCell adhesionCell migrationCytokinesisReceptor traffickingRegulation of integrin internalization/recyclingAutophagyNeurite growthRegulation of Toll-like receptor and EGFR trafficking
04
Disease associations
CancerGliomaColorectal cancerHepatocellular carcinomaNeurodevelopmental disordersCarpenter syndromeCharcot-Marie-Tooth disease
05
Safety considerations
No established safety concerns related to direct drug targetingpotential issues may arise from global disturbance of vesicular trafficking, cell adhesion, proliferation, or neuronal development
06
Interacting drugs
None currently established as directly targeting RAB21
07
Biomarkers
Expression level in glioma (poor prognosis)Downregulation by miR-200b
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