Ras-related protein Rab-24 (RAB24)

Ras-related protein Rab-24 (RAB24) is an atypical small GTPase of the Rab family within the Ras superfamily, located on chromosome 5[1][5]. RAB24 is involved in the regulation of intracellular vesicle trafficking, with a particularly important role in the clearance of late autophagic vacuoles and regulation of basal autophagy[2][5]. It differs from other Rab proteins in its low GTPase activity and preference for the GTP-bound state, and has unique post-translational modification properties[4]. RAB24 is implicated in membrane trafficking events necessary for cellular homeostasis and is associated with diseases such as cancer, ataxia, and infections[2][3][5]. It interacts with several proteins involved in membrane fusion, suggesting roles in autophagosome-lysosome fusion and late endosome function[2]. No drugs are currently known to directly target RAB24, nor is it generally used as a clinical biomarker or associated with specific drug mechanism of action, but it is recognized as a therapeutic target in research settings given its roles in pathological states and essential cell processes[2][3][5].

Other names

RAB24rab24ras-related protein Rab-24

Not specifically characterized for drugs, but molecular mechanism involves GTP binding/hydrolysis to regulate autophagic and endosomal trafficking pathways