Ras-related protein Rab-2B (RAB2B)

Ras-related protein Rab-2B (RAB2B) is a small GTPase of the Rab family, within the Ras GTPase superfamily[1][3]. RAB2B is essential for protein transport from the endoplasmic reticulum to the Golgi complex and is also required for the assembly and function of cilia, by regulating the entry of intraflagellar transport (IFT) complex B into cilia[1][2][3]. In its GTP-bound form, RAB2B helps coordinate membrane trafficking, vesicle docking, and fusion processes, and interacts with a variety of effector proteins, including the IFT-B complex and CEP19—critical for ciliary assembly and cellular compartmentalization[2][3]. Disruption of RAB2B function has been shown to cause defects in ciliogenesis and is associated with ciliary dysfunction in model organisms[2]. Human RAB2B is expressed in multiple tissues, including kidney, prostate, lung, thymus, and colon, with overexpression noted in certain cancers[1]. Diseases associated with RAB2B include chromosomal anomalies, but it is not a currently recognized therapeutic target (e.g., drug, enzyme, receptor), and there are no known drug interactions[3]. RABL2B is a close paralog of RABL2A but is distinct from the canonical RAB2B. The queried term "RAB, member of RAS oncogene family like 2B" is non-standard and likely refers to "Ras-related protein Rab-2B (RAB2B)," not a canonical drug target or receptor[1][3].

Other names

RABL2BRab-like protein 2Brab-like protein 2BRAB2BRAB protein-GTP binding proteinRAS protein