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Target intelligence / Profile preview
Ras-related protein Rab-33A (RAB33A)
- Target
- RAB33A
- Molecular classification
- Small GTPase, Rab family, Enzyme (GTPase), Other
01
Overview
Ras-related protein Rab-33A (RAB33A) is a member of the small GTPase superfamily, Rab family. This protein functions as a GTP-binding GTPase and is involved in vesicle transport and regulation of intracellular membrane trafficking. Expression is seen in several brain regions. Mutations in RAB33A are associated with Charcot-Marie-Tooth disease, X-linked recessive type 4, with or without cerebellar ataxia. There is no evidence to support its status as a direct therapeutic target or a receptor, but it plays an essential cellular role in vesicular transport processes.
- Other names
- RAB33ARabS10Small GTP-binding protein S10Ras-related protein Rab-33ARAB 33ARabS 10Rab33aMGC1488
02
Biological functions
Vesicle transportIntracellular membrane traffickingGTP bindingGTPase activityRegulation of vesicle-mediated transport
03
Disease associations
Charcot-Marie-Tooth disease X-linked recessive 4Charcot-Marie-Tooth disease X-linked recessive 4 with or without cerebellar ataxiaOther
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