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Ras-related protein Rab-40A-like (RAB40AL)
- Target
- RAB40AL
- Molecular classification
- Small monomeric GTPase, Rab family, Ras superfamily, SOCS box protein
01
Overview
Ras-related protein Rab-40A-like (RAB40AL) is a small GTP-binding protein belonging to the Rab40 subfamily, distinguished by a C-terminal SOCS box domain. It likely acts as a substrate-recognition component of an ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex, mediating ubiquitination and proteasomal degradation of target proteins. RAB40AL's biological role is inferred from its close similarity to Rab40A, with potential involvement in actin cytoskeleton regulation and cell migration, but specific functions remain poorly studied. Research to date has focused primarily on Rab40A and its family members, so the unique roles of Rab40AL are not well defined, and it is not an established therapeutic target[1][2][3][7].
- Other names
- RAB40A-likeRAB40ALRLGPRAR2Ras-like GTPaseMRXSMPSOCS box containing protein RAR2ras-related protein Rab-40A-like
02
Mechanism of action
Not applicable; no drugs targeting RAB40AL are known.
03
Biological functions
Protein ubiquitination (as part of the ECS E3 ubiquitin ligase complex)Regulation of actin cytoskeletonModulation of cell migration machinery
04
Disease associations
Related to Martin-Probst Syndrome (other Rab40 proteins)Cancer (potentially, by analogy with Rab40A's roles in migration and adhesion)Other roles are not well characterized directly for RAB40AL
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