Ras-related protein Rab-43 (RAB43)

Ras-related protein Rab-43 is a small GTPase enzyme and a member of the Rab family, which functions as a key regulator of intracellular membrane trafficking[1][3][7]. Rab-43 cycles between inactive GDP-bound and active GTP-bound forms, recruiting effectors that mediate transport vesicle formation, movement, tethering, and fusion with target membranes[1][7]. The protein is involved in retrograde transport, particularly from endocytic compartments to the Golgi apparatus, and is required for the structural integrity of the Golgi complex[1][3][7]. It also plays a role in maturation of phagosomes, notably those that engulf pathogens such as Staphylococcus aureus and Mycobacterium tuberculosis[1]. Although there are disease associations (e.g., certain cancers, Lynch syndrome 5, Smith-McCort dysplasia), there are currently no approved drugs listed as directly targeting this molecule[1][5][7].

Other names

RAB43Ras-related protein Rab-43RAB41Ras-related protein Rab-41RAB11BISY1

No drugs with defined mechanisms of action specifically targeting RAB43 are reported in public literature or databases[1][7].