Ras-related protein Rab-5C (RAB5C)

Ras-related protein Rab-5C (RAB5C) is a small GTPase of the Rab family within the Ras superfamily, acting as a key regulator of intracellular membrane trafficking, particularly endocytosis and vesicle fusion[1][7]. RAB5C cycles between inactive (GDP-bound) and active (GTP-bound) forms, coordinating the docking and/or fusion of vesicles to their correct membrane compartments[1][2][7]. It plays a master role in the endocytic pathway, including the uptake of extracellular materials, recycling or degradation of membrane proteins and signal transduction, notably through growth factor receptors such as EGF and VEGF[2]. RAB5C is expressed broadly in human tissues including the nervous system, vasculature, and various organ systems[8]. Pathogenic variants in RAB5C are associated with neurodevelopmental disorders, most notably macrocephaly, developmental delay, and epilepsy, and have also been implicated in cancer cell proliferation and response to viral infection[1][2][6][9].

Other names

RABLRAB5CLRAB5LL1880RAB5Cmember RAS oncogene familyras-related protein Rab-5C

No known approved drugs with direct mechanism of action; implicated in disease modulation through regulation of endocytosis, trafficking, and signal transduction