Ras-related protein Rab-6A (RAB6A)

Ras-related protein Rab-6A (RAB6A) is a small GTPase belonging to the Rab family, involved in the regulation of vesicular transport processes, particularly trafficking between the Golgi apparatus, endosomes, and the endoplasmic reticulum[1][2][3]. RAB6A localizes to the Golgi and modulates both retrograde (Golgi-to-ER) and anterograde (Golgi-to-plasma membrane) transport, ensuring correct delivery and recycling of proteins[1][2][3]. It binds effectors such as myosin II and specifically interacts with Rabkinesin-6 to modulate microtubule-dependent recycling processes[2][3]. Functional disruption of RAB6A affects Golgi structure and protein secretion, with relevance in several diseases, mainly Cohen syndrome and choroideremia, and implications in viral lifecycle (human cytomegalovirus assembly)[1][2][3]. RAB6A is ubiquitously expressed and is essential for normal vesicle trafficking in eukaryotic cells[3]. Key data illustrated in evidence from genetic, biochemical, and cell biology studies, with no current direct drug targeting or biomarker applications[1][2][3].

Other names

Rab-6ARAB6ARAB6Rab-6ras-related protein Rab-6ARab GTPase, member RAS oncogene family