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Target intelligence / Profile preview
Ras-related protein Rab-6B (RAB6B)
- Target
- RAB6B
- Molecular classification
- Small GTPase, Enzyme, Rab protein (Ras superfamily)
01
Overview
Ras-related protein Rab-6B (RAB6B) is a member of the Rab family of small GTPases, which are key regulators of intracellular membrane trafficking, specifically from the formation of transport vesicles to their fusion with target membranes. RAB6B cycles between active (GTP-bound) and inactive (GDP-bound) states and is involved in Golgi apparatus organization, retrograde transport at the Golgi complex, and protein localization to the Golgi membrane. RAB6B is predominantly expressed in the brain (notably in microglia, pericytes, and Purkinje cells) and displays tissue and cell-type specificity. It plays a role in neuron projection development and may function in retrograde transport in neuronal cells. RAB6B is dysregulated in various tumors, has been associated with hepatocellular carcinoma, and can serve as a potential prognostic and diagnostic biomarker for HCC. Mutations or altered expression of RAB6B are linked to Charcot-Marie-Tooth disease type 2K and Cohen syndrome
- Other names
- RAB6B, member RAS oncogene familyrab6bsmall GTPase RAB6Bsmall GTP-binding proteinras-related protein Rab-6B
02
Biological functions
Intracellular membrane traffickingGolgi organizationProtein localization to Golgi membraneRetrograde transport at Golgi complexNeuron projection developmentMyosin V binding
03
Disease associations
Cancer (including hepatocellular carcinoma and potentially other tumors)Charcot-Marie-Tooth disease, axonal, type 2KCohen syndrome
04
Biomarkers
Prognostic biomarker in hepatocellular carcinoma (HCC)Diagnostic biomarker in HCC
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