Ras-related protein Rap-2a (RAP2A)

Ras-related protein Rap-2a (RAP2A) is a small GTPase in the Ras superfamily, cycling between an inactive GDP-bound state and an active GTP-bound state[2][1][6]. In its GTP-bound form, it interacts with multiple effectors, including MAP4K4, MINK1, and TNIK, regulating diverse signaling cascades, including those governing cytoskeletal organization, cell migration, and dendrite morphogenesis[2]. RAP2A is involved in microvillus assembly and neuron development, and acts in various tissues, such as at the plasma membrane and in endosomal compartments[2][3]. Disease associations include roles in certain cancers (notably breast cancer and glioma) and intellectual developmental disorders[2][7]. No small molecule drugs are currently established as targeting RAP2A directly, but its molecular network offers potential future targeting strategies. Safety challenges in targeting RAP2A may arise due to its fundamental role in cell signaling and morphology[2][7].

Other names

K-REVRbBP-30RAP2ras-related protein Rap-2aRAP2, member of RAS oncogene family (K-rev)Ras-related protein 2a5830461H18RIK

Not established for any drugs; as a GTPase, potential mechanisms would involve modulation of its GTPase activity or interference with its protein interactions[2].