RasGEF domain family member 1B (RASGEF1B)

RasGEF domain family member 1B (RASGEF1B) is an enzyme classified as a guanine nucleotide exchange factor (GEF) that specifically activates the small GTPase Rap2 by facilitating the exchange of GDP for GTP[1][2][4]. It contains a CDC25-Ras exchange motif domain and an N-terminal RasGEF-N domain[4]. RASGEF1B is highly expressed in macrophages, where it plays a role in basal and stimulus-induced gene expression, particularly in response to innate immune activation via Toll-like receptor (TLR) pathways and NF-κB signaling[2][3]. Its associated circRNA is robustly induced by inflammatory stimuli (e.g., LPS) and modulates the expression of genes like ICAM-1, affecting immune cell behavior[1][2]. Genetic studies suggest a role for RASGEF1B in cardiovascular regulation and potentially, in the etiology of developmental syndromes when deleted as part of larger chromosomal aberrations[1]. Its primary biological actions center on regulating Rap2-mediated signaling, immune transcriptional programs, and possibly vascular and developmental processes, though no drugs are currently known to directly target this protein[1][2][4].

Other names

Ras-GEF domain-containing family member 1BGPIG4GPI gamma-4FLJ31695RGF1B_HUMAN

Guanine nucleotide exchange (specifically for Rap2 GTPase)