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RASSF1 antisense RNA 1 (RASSF1-AS1)
- Target
- RASSF1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
RASSF1 antisense RNA 1 (RASSF1-AS1) is a long non-coding RNA transcribed from the opposite strand of the RASSF1 gene locus at 3p21.3. It functions primarily by forming antisense RNA interactions with the RASSF1A mRNA, thereby suppressing its translation and promoting gene silencing at the epigenetic level by recruiting PRC2 complex component SUZ12, which locally increases H3K27me3 repressive histone marks at the RASSF1A promoter[5][1]. RASSF1-AS1 is upregulated in disease states such as cardiac fibrosis, where it promotes pathological remodeling by inhibiting the tumor suppressor activity of RASSF1A[1]. Its expression is also higher in triple negative breast cancer samples, marking it as a potential cancer biomarker[5]. RASSF1-AS1 is localized in the nucleus and is usually unspliced and polyadenylated[5]. Currently, there are no known drugs directly targeting RASSF1-AS1, and its mechanistic functions relate to gene regulation rather than acting as a classic therapeutic target like a receptor or enzyme.
- Other names
- ANRASSF1RASSF1-AS1
02
Biological functions
Regulation of gene expression (specifically RASSF1A)Epigenetic modulation via recruitment of polycomb repressive complex 2 (PRC2) component SUZ12Suppression of translation of RASSF1A mRNAPromotion of cell proliferationInteraction with nuclear factor-κB activation
03
Disease associations
Cancer (e.g., roles in breast cancer, suggested as a cancer biomarker)Cardiac fibrosis (associated with exacerbation of cardiac fibrosis)
04
Biomarkers
Elevated expression in triple negative breast cancer (proposed biomarker role)
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