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Target intelligence / Profile preview
Rat Lens Aldose Reductase (RLAR)
- Target
- RLAR
- Molecular classification
- Enzyme, Alditol:NADP+ oxidoreductase
01
Overview
Rat lens aldose reductase (RLAR) is an enzyme that catalyzes the reduction of glucose to sorbitol, a key step in the polyol pathway. It is implicated in the development of diabetic complications, particularly cataracts, due to the accumulation of sorbitol in the lens. RLAR also participates in detoxification of aldehydes and antioxidant defense. It is a target for aldose reductase inhibitors, which aim to prevent or delay these complications.
02
Mechanism of action
Inhibition of aldose reductase, preventing the conversion of glucose to sorbitol
03
Biological functions
Reduction of glucose to sorbitolDetoxification of lipid peroxidation-derived aldehydesAntioxidant defense
04
Disease associations
Diabetic cataractsDiabetic retinopathyDiabetic neuropathyDiabetic nephropathy
05
Interacting drugs
Kaempferol glycoside
5 more in the full profile.
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