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Rat Sarcoma (Ras)

Target: Ras
Molecular classification: Small GTPase, Signaling protein

Overview

Ras refers to a family of small GTPase proteins that act as molecular switches in numerous cellular signaling pathways. These proteins are highly conserved across eukaryotes and play essential roles in regulating cell growth, differentiation, and survival. Mutations in RAS genes are among the most common oncogenic events in human cancers.

Other names: K-RasH-RasN-Ras

Mechanism of action

Inhibition of GTP binding or hydrolysis

Biological functions

Signal transductionCell growthCell differentiationCell survival

Disease associations

Cancer

Safety considerations

Resistance to targeted therapiesOff-target effects

Biomarkers

KRAS mutation statusNRAS mutation status

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