RBM26 antisense RNA 1 (RBM26-AS1)

RBM26 antisense RNA 1 (RBM26-AS1) is a long non-coding RNA located on chromosome 13q31.1, transcribed antisense to the protein-coding RBM26 gene[4]. While previously annotated as non-protein coding, recent studies demonstrate that RBM26-AS1 may encode short micropeptides that promote colon cancer cell growth by enhancing nucleocytoplasmic transport and protein processing in the endoplasmic reticulum[2]. There is currently no known specific biological function assigned to the lncRNA itself in normal physiology, though it likely regulates gene expression of RBM26 and possibly other related genes, consistent with mechanisms observed for antisense RNAs[3][7]. As of now, RBM26-AS1 is not considered a classical therapeutic target, and no clinical drugs interact with it directly[2][4][7].

Other names

RBM26 antisense RNA 1 (non-protein coding)RBM26-AS1

For antisense oligonucleotides (ASOs) targeting antisense RNAs: RNA degradation via RNase H, modulation of RNA stability, interference with mRNA translation. The RBM26-AS1-encoded micropeptide may enhance nucleocytoplasmic transport and ER protein processing.