RBMS3 antisense RNA 3 (RBMS3-AS3)

RBMS3 antisense RNA 3 (RBMS3-AS3) is a long non-coding RNA transcribed antisense to the RBMS3 gene, and is not translated into protein. RBMS3-AS3 has been implicated in cancer biology, especially as a tumor suppressor in prostate cancer, where it inhibits proliferation, migration, invasion, and tumorigenesis by acting as a microRNA-4534 sponge. Its upregulation leads to increased expression of VASH1, an anti-angiogenic protein. While its main role appears regulatory at the transcript level, especially via competing endogenous RNA networks, more research may clarify its function in other diseases or pathways.

Other names

RBMS3 antisense RNA 3 (non-protein coding)RBMS3-AS3

Acts as a ceRNA/microRNA sponge for miR-4534, relieving inhibition of VASH1 (vasohibin 1), thereby inhibiting cancer cell progression