RBPJ-interacting and tubulin-associated protein 1 (RITA1)

RBPJ-interacting and tubulin-associated protein 1 (RITA1) is a highly conserved cytoplasmic and nuclear protein that binds tubulin and modulates the stability and dynamics of microtubules[2][5][9]. RITA1 functions as a negative regulator of the Notch signaling pathway by binding to the transcription factor RBPJ (also known as CSL), promoting its export from the nucleus, and interfering with the assembly of Notch transcriptional activator complexes, ultimately reducing the expression of Notch target genes[1][2][9]. Beyond transcriptional regulation, RITA1 is instrumental in organizing the cytoskeleton and participates in processes such as cell migration, invasion, cell cycle progression, and mitosis by influencing microtubule and spindle formation[1][3]. Dysregulation or aberrant expression of RITA1 affects tumor biology in a context-dependent manner (e.g., tumor suppressive in hepatocellular carcinoma, tumor promoting in bladder cancer)[1][6]. RITA1 is also essential in placental development and defects are associated with early-onset preeclampsia[1]. There are currently no approved drugs known to directly target RITA1 and it is not considered a classical therapeutic target such as a receptor or enzyme[2][5][9].

Other names

C12orf52RITAFLJ14827PSEC0043RBPJ-interacting and tubulin-associated proteinRBP-J interacting and tubulin-associated proteinRITA1_HUMAN