RBPMS antisense RNA 1 (RBPMS-AS1)

RBPMS antisense RNA 1 (RBPMS-AS1) is a long noncoding RNA (lncRNA) transcribed from the antisense strand at the RBPMS (RNA-binding protein with multiple splicing) gene locus. As a regulatory RNA, RBPMS-AS1 does not encode a protein but modulates gene expression through molecular interactions with microRNAs and possibly mRNAs, influencing various pathways in cellular proliferation, differentiation, apoptosis, and tumorigenesis. Specifically, in glioblastoma, RBPMS-AS1 has been shown to act as a molecular "sponge" for miR-301a-3p, thereby relieving miRNA-mediated suppression of CAMTA1 and ultimately promoting NRGN expression, which enhances tumor cell radiosensitivity and apoptosis while suppressing proliferation. RBPMS-AS1 is expressed at reduced levels in glioblastoma and other tumors and is under active study as a potential biomarker or functional gene in cancer biology, but it is not a druggable or classical therapeutic target at this time.

Other names

TP53LC06CTD-3107M8.4RBPMS-AS1

Not applicable for drug action; functionally, RBPMS-AS1 acts as a "competing endogenous RNA" (ceRNA) or molecular sponge for specific microRNAs, such as miR-301a-3p, which in turn regulate downstream effectors (e.g., CAMTA1, NRGN)