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RdRp Thumb-1 site

Molecular classification: Enzyme, RdRp Subdomain

Overview

The RdRp Thumb-1 site refers to a specific region within the thumb subdomain of RNA-dependent RNA polymerase (RdRp), an essential enzyme for the replication of RNA viruses. The thumb subdomain plays roles in template stabilization, initiator element in some viruses, and post-catalytic translocation. It is being explored as an allosteric drug target to inhibit viral replication.

Mechanism of action

Allosteric inhibition of RdRp activity; disruption of template binding/translocation

Biological functions

Template stabilizationInitiator element (in some)Post-catalytic translocationViral genome replication

Disease associations

Infection

Safety considerations

Potential for resistance developmentOff-target effects due to structural similarities with other polymerases

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