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Astrocyte Activation
- Molecular classification
- Other
01
Overview
Astrocyte activation refers to a process in which astrocytes, a type of glial cell in the central nervous system (CNS), undergo changes in morphology, gene expression, and function in response to various stimuli such as cytokines, chemokines, cellular ligands, soluble factors, injury, or disease. This process is also known as "reactive astrogliosis" or "astroglial activation".
- Other names
- Reactive AstrogliosisAstroglial Activation
02
Biological functions
CNS homeostasisNeural repairWound healingScar formation (gliosis)Modulation of synaptic activityRegulation of blood-brain barrier integrityNeuroinflammation
03
Disease associations
Stroke/IschemiaEpilepsyAlzheimer's diseaseBrain tumors/GliomasTraumatic injuriesNeurodegenerationInflammation
04
Safety considerations
Inhibition of axon regenerationContribution to glial scar/tumor growthPromoting inflammation/neurodegeneration
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