Reactive Oxygen Species Pathway

The reactive oxygen species (ROS) pathway refers to the network of biochemical processes involving the generation, regulation, and signaling functions of ROS within biological systems. ROS are produced as natural byproducts of cellular metabolism and play dual roles: at physiological levels, they act as signaling molecules; at excessive levels, they cause oxidative stress and cellular damage. Key components include superoxide, hydrogen peroxide, and hydroxyl radical. Regulators include NADPH oxidases and mitochondrial respiratory chain complexes. The pathway influences processes such as cell proliferation, differentiation, apoptosis, and immune response and is implicated in diseases such as cardiovascular disease, neurodegeneration, and cancer. Therapeutic strategies involve modulating ROS production or scavenging ROS.

Other names

ROS PathwayOxidative Stress PathwayRedox Signaling Pathway

Modulation of ROS production, scavenging of ROS, or targeting downstream signaling molecules.