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Target intelligence / Profile preview
Rearranged during Transfection (RET)
- Target
- RET
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
RET (Rearranged during Transfection) is a receptor tyrosine kinase that plays essential roles in cell proliferation, differentiation, survival, migration, and metabolism. It is the canonical signaling receptor for members of the glial cell line-derived neurotrophic factor (GDNF) family of ligands. Mutations or rearrangements involving RET can lead to constitutive activation or loss-of-function: Gain-of-function mutations are associated with multiple endocrine neoplasia type 2 (MEN2), medullary thyroid carcinoma, papillary thyroid carcinoma. Loss-of-function mutations cause Hirschsprung’s disease due to impaired enteric neuron development.
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationCell differentiationCell survivalCell migrationMetabolismKidney morphogenesisNervous system development
04
Disease associations
Multiple endocrine neoplasia type 2 (MEN2)Medullary thyroid carcinomaPapillary thyroid carcinomaHirschsprung’s diseaseCancer
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