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Target intelligence / Profile preview
REarranged during Transfection Growth Factor Receptor (RET)
- Target
- RET
- Molecular classification
- Receptor tyrosine kinase
01
Overview
The REarranged during Transfection (RET) receptor is a transmembrane receptor tyrosine kinase that plays a critical role in the development and maturation of various tissues, particularly those derived from the neural crest. It is essential for cell proliferation, neuronal navigation, migration, and differentiation. Aberrant activation of RET, often through gene fusions or mutations, can drive tumorigenesis, making it an important therapeutic target in cancers like NSCLC and thyroid cancer. Selective RET inhibitors are now used to treat these cancers.
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell growthCell proliferationCell differentiationCell migrationNeuronal navigationSurvival
04
Disease associations
CancerMultiple endocrine neoplasia type 2 syndromesMedullary thyroid carcinomaPapillary thyroid carcinomaNon-small cell lung cancer
05
Safety considerations
Response rates vary depending on tumor type/genetic contextPotential adverse effects of tyrosine kinase inhibitors
06
Interacting drugs
Pralsetinib
3 more in the full profile.
07
Biomarkers
RET fusions (e.g., KIF5B-RET, CCDC6-RET, NCOA4-RET)RET mutations
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