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Target intelligence / Profile preview
Rearranged during Transfection Proto-oncogene Protein (RET)
- Target
- RET
- Molecular classification
- Receptor tyrosine kinase
01
Overview
The Rearranged during Transfection proto-oncogene protein (RET) is a receptor tyrosine kinase that plays a critical role in cell growth, differentiation, and survival. Aberrant activation or mutation leads to constitutive signaling associated with several cancers, including papillary thyroid carcinoma, medullary thyroid carcinoma, and non-small cell lung cancer. Selective RET inhibitors like pralsetinib and selpercatinib are used to target mutant or fusion forms of the protein.
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Signal transductionCell growthCell differentiationCell survivalCell proliferationCell motilityCell migration
04
Disease associations
CancerHirschsprung's diseasePapillary thyroid carcinomaMedullary thyroid carcinomaMultiple endocrine neoplasia types 2A & 2BPheochromocytomaParathyroid hyperplasiaNon-small cell lung cancer
05
Safety considerations
Resistance to inhibitorsOff-target effects of multi-kinase inhibitors
06
Interacting drugs
Pralsetinib
3 more in the full profile.
07
Biomarkers
RET fusionsRET mutations
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