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Target intelligence / Profile preview
Rearranged during Transfection Proto-oncogene Tyrosine-Protein Kinase Receptor (RET)
- Target
- RET
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Proto-oncogene
01
Overview
RET encodes a receptor tyrosine kinase vital to neural development but also implicated as an oncogenic driver when mutated or aberrantly activated through gene fusion events. Its role as both a developmental regulator and cancer driver makes it an important target for genetic screening programs as well as precision oncology therapeutics using selective small-molecule inhibitors.
02
Mechanism of action
Selective RET kinase inhibitors
03
Biological functions
Signal transductionCell growthCell differentiationCell survivalNeural crest developmentKidney morphogenesis
04
Disease associations
CancerMultiple Endocrine Neoplasia type 2A/2BPapillary Thyroid CarcinomaNon-Small Cell Lung CancerHirschsprung’s Disease
05
Safety considerations
Resistance to RET inhibitors due to secondary mutationsOff-target effects of RET inhibitors
06
Interacting drugs
Selpercatinib
1 more in the full profile.
07
Biomarkers
RET mutations (e.g., M918T)RET fusions (e.g., KIF5B-RET, CCDC6-RET)
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