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Recepteur d’Origine Nantais (RON)
- Target
- RON
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK), MET proto-oncogene family RTKs
01
Overview
Recepteur d’Origine Nantais (RON), also known as MST1R, is a receptor tyrosine kinase belonging to the MET proto-oncogene family. It is a heterodimeric protein activated by its ligand, Macrophage Stimulating Protein (MSP), leading to downstream signaling through pathways like PI3K/AKT and MAPK, influencing cell growth, survival, and inflammation. RON is implicated in cancer progression and metastasis, making it a therapeutic target of interest.
- Other names
- MST1RMacrophage-stimulating protein receptor (MSPR)PTK8MSP-R
02
Mechanism of action
Tyrosine kinase inhibition (potential)
03
Biological functions
Signal transductionCell adhesionCell motilityCell invasionApoptosis regulationCell proliferationCell survivalInflammation attenuationEpithelial development
04
Disease associations
CancerTumorigenesisInflammation
05
Safety considerations
Potential for off-target effects due to kinase similarityAberrant splicing variants may impact drug targeting
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