Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Recepteur d’Origine Nantais proto-oncogene Receptor Tyrosine Kinase (RON)
- Target
- RON
- Molecular classification
- Receptor tyrosine kinase (RTK), MET proto-oncogene family
01
Overview
Recepteur d’Origine Nantais (RON) is a receptor tyrosine kinase (RTK) belonging to the MET proto-oncogene family. It is activated by macrophage-stimulating protein (MSP) and plays a crucial role in cell growth, survival, migration, and inflammation. Aberrant RON activation is implicated in various cancers, making it a potential therapeutic target. Splice variants of RON, such as RONΔ165 and RONΔ160, can exhibit constitutive activity and contribute to tumor progression.
- Other names
- MST1RMacrophage-stimulating protein receptor
02
Mechanism of action
Inhibition of RON kinase activity, blocking downstream signaling pathways
03
Biological functions
Growth factor signalingInflammatory responsesCell proliferationCell survivalCell migrationCell invasionAngiogenesis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to RTK family similaritiesDevelopment of resistance mechanismsImmune-related adverse events
06
Biomarkers
RON expression levels in tumor tissueRON splice variants (e.g., RONΔ165)Phosphorylation status of RON (e.g., p-Tyr1238/1239)
Beyond the preview
Go deeper on Recepteur d’Origine Nantais proto-oncogene Receptor Tyrosine Kinase (RON).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Recepteur d’Origine Nantais proto-oncogene Receptor Tyrosine Kinase (RON).