Receptor accessory protein 3 (REEP3)

Receptor accessory protein 3 (REEP3) is a microtubule-binding protein required for proper cell division and reassembly of the nuclear envelope during mitosis. It likely acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes, ensuring that mitosis proceeds without interference from the ER. REEP3 is predicted to localize to the endoplasmic reticulum and participate in nuclear membrane reassembly. Diseases associated with mutations in the REEP3 gene include adult hypophosphatasia, autism, and hereditary spastic paraplegia. There is no evidence to suggest REEP3 plays a direct role as a drug target, nor as a classical accessory protein for cell-surface receptors. Important note on ambiguity: The term "receptor accessory protein" is classically associated with RAMP (Receptor activity-modifying proteins), especially RAMP3. RAMP3 is a true GPCR receptor accessory protein, involved in modifying receptor pharmacology and trafficking, and is a recognized therapeutic target (e.g., for pramlintide). REEP3 and RAMP3 are distinct genes with unrelated molecular functions, although both have "receptor accessory" in their expanded names. The usage "receptor accessory protein 3" for REEP3 can lead to confusion in the biomedical literature. If a pharmacological target is needed, RAMP3 ("Receptor activity-modifying protein 3") is the correct entity. If "receptor accessory protein 3" maps to REEP3, this is not a classical pharmacological target. For additional targets such as receptor transporting proteins (RTPs), or olfactory accessory proteins, see [5], but these should not be conflated with REEP3.

Other names

REEP3C10orf74

Not applicable; no established drugs target REEP3