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Target intelligence / Profile preview
Receptor Activator of Nuclear Factor-kappaB (RANK)
- Target
- RANK
- Molecular classification
- Tumor necrosis factor receptor superfamily member, Receptor
01
Overview
Receptor Activator of Nuclear Factor-kappaB (RANK) is a type I transmembrane receptor expressed on osteoclast precursors and mature osteoclasts. It is essential for osteoclast differentiation, activation, and survival. Binding of its ligand, RANKL, initiates signaling cascades that lead to the expression of genes required for osteoclastogenesis and bone resorption. OPG acts as a decoy receptor for RANKL, inhibiting its interaction with RANK.
- Other names
- TNFRSF11ACD265TRANCE receptorOsteoclast differentiation factor receptorODAR
02
Mechanism of action
Inhibition of RANKL binding to RANK, preventing osteoclast formation and bone resorption
03
Biological functions
Osteoclast differentiationOsteoclast activationBone remodelingSignal transductionNF-κB signalingAP-1 signalingNFAT signaling
04
Disease associations
OsteoporosisOsteopetrosisSkeletal diseasesBone loss
05
Safety considerations
Increased risk of infectionsHypocalcemiaOsteonecrosis of the jawAtypical femoral fractures
06
Interacting drugs
Denosumab
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