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Target intelligence / Profile preview
Receptor-Binding Domain of Spike Glycoprotein (RBD)
- Target
- RBD
- Molecular classification
- Protein Domain, Viral Protein, Glycoprotein
01
Overview
The receptor-binding domain (RBD) is a critical region within the spike (S) glycoprotein of coronaviruses, including SARS-CoV-2. It is responsible for binding to host cell receptors, facilitating viral entry into target cells. The RBD is located within the S1 subunit of the spike protein and directly interacts with cellular receptors such as angiotensin-converting enzyme 2 (ACE2) in SARS-CoV-2. It is a major target for neutralizing antibodies and a key component in vaccine development.
- Other names
- Spike RBDS1-RBDSARS-CoV-2 RBD
02
Mechanism of action
Binds to host cell receptor (ACE2) to mediate viral entry. Target of neutralizing antibodies that block this interaction.
03
Biological functions
Receptor bindingViral entryImmune recognitionHost cell attachment
04
Disease associations
InfectionCOVID-19
05
Safety considerations
Potential for antibody-dependent enhancement (ADE) of infectionEvasion by viral mutations
06
Interacting drugs
Neutralizing antibodies (e.g., S309)
1 more in the full profile.
07
Biomarkers
RBD-binding antibodiesNeutralizing antibody titers
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