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Target intelligence / Profile preview
Receptor-Binding Domain of the Spike Glycoprotein (RBD)
- Target
- RBD
- Molecular classification
- Viral protein, Glycoprotein, Receptor-binding domain
01
Overview
The receptor-binding domain (RBD) is a critical region within the spike (S) glycoprotein of SARS-CoV-2, responsible for mediating the virus's attachment to host cells. It binds to the ACE2 receptor on human cells, initiating viral entry. The RBD is also a major target for neutralizing antibodies and vaccines. The spike glycoprotein—including its RBD—is heavily glycosylated playing roles in proper folding, immune evasion (“glycan shield”), antibody recognition, and modulating conformational dynamics important for receptor engagement.
- Other names
- SARS-CoV-2 RBDSpike RBDS1 RBD
02
Mechanism of action
Binding to ACE2 receptor, blocking ACE2 interaction, eliciting neutralizing antibodies
03
Biological functions
Receptor bindingViral entryImmune recognitionAntigen presentation
04
Disease associations
COVID-19Viral infectionImmune evasion
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Risk of immune escape variantsOff-target effects of antibodies
06
Interacting drugs
Neutralizing antibodies
2 more in the full profile.
07
Biomarkers
RBD-specific antibody titersACE2 binding affinityNeutralization assay results
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