Receptor expression-enhancing protein 2 (REEP2)

Receptor expression-enhancing protein 2 (REEP2) is a member of the DP1/Yop1p family of endoplasmic reticulum (ER)-shaping proteins, characterized by two highly conserved hydrophobic domains that promote membrane curvature within the ER[2][3]. REEP2 plays a role in the formation, shaping, and remodeling of the ER network, particularly through interactions with other membrane proteins such as atlastin and spastin[2][4]. REEP2 may enhance the cell surface expression of certain G protein-coupled receptors, including specific odorant and taste receptors, although this function is supported primarily by studies in model organisms[3][7]. REEP2 is highly expressed in the brain and testis[2][6]. Pathogenic variants or loss of function in REEP2 cause hereditary spastic paraplegia (notably, Spastic Paraplegia 72), likely due to its loss of ER-membrane shaping activity which leads to ER network defects and neuronal degeneration[2][3][4]. **Notes:** - REEP2 is not a classical receptor, ion channel, enzyme, or transporter; rather, it is an accessory/adaptor protein involved in ER structure and trafficking. - No approved therapeutic drugs or direct pharmacological modulators of REEP2 are currently known. - Its major clinical relevance is as a genetic cause for certain hereditary spastic paraplegias, not as a direct therapeutic target.

Other names

Receptor accessory protein 2REEP2C5orf19SGC32445SPG72Yip2dSPG72ASPG72B