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Receptor expression-enhancing protein 4 (REEP4)
- Target
- REEP4
- Molecular classification
- Other (Endoplasmic reticulum membrane protein, microtubule-binding protein, Reticulon homology domain protein)
01
Overview
Receptor expression-enhancing protein 4 (REEP4) is an endoplasmic reticulum (ER) membrane protein characterized by a dual hairpin structure and a reticulon homology domain. REEP4 binds microtubules and is necessary for proper cell division, particularly by ensuring mitotic nuclear membrane reassembly and sequestering ER away from metaphase chromosomes. During mitosis, REEP4—together with its paralog REEP3—induces high-curvature ER tubules and positions the ER away from chromatin, roles that are physically separable through different protein regions. REEP4 has no known direct interactions with therapeutics and is not typically classified as a traditional drug target, receptor, or enzyme. Genetic disruption of REEP4 is linked to rare syndromes such as autosomal dominant spastic paraplegia 31 and hereditary lymphedema II. The protein plays a critical role in cell cycle-dependent ER remodeling and nuclear dynamics.
- Other names
- C8orf20PP432FLJ22246FLJ22277Yip2creceptor accessory protein 4
02
Biological functions
Mitotic nuclear membrane reassemblyMaintenance of endoplasmic reticulum (ER) morphologyPromotion of high-curvature ER during mitosisSequestration of ER from metaphase chromosomesFacilitation of nuclear pore complex (NPC) assembly during mitosis
03
Disease associations
Spastic paraplegia 31, autosomal dominantHereditary lymphedema IIOther (no widely confirmed or direct disease role outside rare genetic disorders)
04
Safety considerations
null (no unique or anticipated safety concerns directly related to modulation; essential for cell division, so off-target effects could be detrimental)
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