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Target intelligence / Profile preview
Receptor for Advanced Glycation End Products (RAGE)
- Target
- RAGE
- Molecular classification
- Receptor, Pattern Recognition Receptor (PRR), Immunoglobulin superfamily
01
Overview
The Receptor for Advanced Glycation End Products (RAGE) is a cell surface receptor belonging to the immunoglobulin superfamily. It acts as a pattern recognition receptor (PRR), capable of binding a wide variety of ligands, including advanced glycation end products (AGEs), amyloid-β peptides, S100/calgranulins, high-mobility group box 1 protein (HMGB1), and other damage-associated molecular patterns (DAMPs). Its sustained expression perpetuates inflammatory responses and oxidative stress, contributing to various chronic inflammatory and metabolic diseases.
02
Mechanism of action
RAGE inhibition via soluble decoy receptors or small molecule inhibitors
03
Biological functions
Signal transductionInflammatory response amplificationMediation of cellular responses to stress signals
04
Disease associations
Diabetes complicationsNeurodegenerative diseaseAlzheimer's diseaseCancer progressionChronic inflammationCardiovascular disorders
05
Safety considerations
Excessive ligand accumulation leading to tissue injuryPotential for off-target effects due to broad ligand specificity
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