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Target intelligence / Profile preview
Receptor for Advanced Glycation Endproducts (RAGE)
- Target
- RAGE
- Molecular classification
- Receptor, Immunoglobulin superfamily, Pattern recognition receptor
01
Overview
Receptor for Advanced Glycation Endproducts (RAGE) is a transmembrane pattern recognition receptor belonging to the immunoglobulin superfamily. It binds to various ligands, including AGEs, S100 proteins, HMGB1, and amyloid β, triggering pro-inflammatory signaling pathways and contributing to the pathogenesis of various diseases, including diabetes complications, cardiovascular disease, neurodegenerative disorders, and cancer. Soluble forms of RAGE (sRAGE or esRAGE) can act as decoy receptors and serve as biomarkers for chronic inflammation.
- Other names
- AGER
02
Mechanism of action
Extracellular/intracellular targeting strategies against RAGE are under investigation therapeutically.
03
Biological functions
Innate immune responseSignal transductionCell proliferationCell migrationInflammatory response
04
Disease associations
Diabetes complicationsCardiovascular diseaseNeurodegenerative diseaseAlzheimer’s diseaseCancerInflammation
05
Safety considerations
Positive feedback loop amplifying inflammation
06
Biomarkers
sRAGEesRAGE
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