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Target intelligence / Profile preview
Receptor for Hyaluronate-Mediated Motility (RHAMM)
- Target
- RHAMM
- Molecular classification
- Receptor, Hyaluronan-binding protein, Intracellular protein, Microtubule-associated protein
01
Overview
The receptor for hyaluronate-mediated motility—commonly known as RHAMM/HMMR—is an evolutionarily conserved regulator involved both inside the cell (mitotic spindle function) and at the interface between cells/extracellular matrix where it mediates responses crucial to development, wound healing—and notably—invasion/metastasis across diverse tumor types through its interaction with hyaluronic acid.
- Other names
- HMMRCD168IHABP
02
Mechanism of action
Targeting HA/RHAMM interactions to modulate inflammation/fibrosis/tumor progression
03
Biological functions
Cell motilityCell migrationMitosisSpindle assemblyHyaluronan bindingSignal transductionCell proliferationExtracellular matrix interaction
04
Disease associations
CancerInflammationFibrosisMetastasis
05
Safety considerations
Incompletely understood export mechanism from cytoplasmPotential for off-target effects due to widespread expression and diverse functions
06
Biomarkers
HMMR mRNA/protein expression levels in cancer cells
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