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Target intelligence / Profile preview
Receptor protein-tyrosine kinase erbB-3 (ERBB3)
- Target
- ERBB3
- Molecular classification
- Receptor, Receptor tyrosine kinase
01
Overview
Receptor protein-tyrosine kinase erbB-3 (ERBB3/HER3) is a member of the epidermal growth factor receptor (EGFR/ERBB) family. It is a receptor tyrosine kinase that, upon activation by neuregulins, primarily heterodimerizes with other ErbB receptors, most notably ErbB2/HER2, to activate downstream signaling pathways, particularly the PI3K/Akt pathway. While it possesses impaired kinase activity, it plays a crucial role in cell survival, proliferation, and drug resistance in various cancers, making it an important therapeutic target.
- Other names
- HER3human epidermal growth factor receptor 3
02
Mechanism of action
Heterodimerization with other ErbB receptors (primarily ErbB2/HER2) leading to activation of PI3K/Akt pathway.
03
Biological functions
Signal transductionCell proliferationCell survivalDevelopmentTissue homeostasis
04
Disease associations
Cancer progressionMetastasisDrug resistance
05
Safety considerations
Acquired resistance to targeted therapiesLow intrinsic kinase activity presents challenges for small molecule inhibitor development
06
Interacting drugs
Neuregulin-1 (NRG1)
2 more in the full profile.
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