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Target intelligence / Profile preview
Receptor protein-tyrosine kinase erbB-4 (HER4)
- Target
- HER4
- Molecular classification
- Receptor Tyrosine Kinase, ErbB/EGF Receptor Family, Type I membrane glycoprotein
01
Overview
HER4, also known as ERBB4, is a member of the ErbB family of receptor tyrosine kinases. It functions as a cell surface receptor for neuregulins and other EGF family ligands. HER4 plays essential roles in development and maintenance of cardiovascular and nervous systems, mammary gland development, regulation of gene transcription, cell proliferation, differentiation, and survival. Its role in cancer is complex, acting as both a tumor suppressor and promoter depending on context. Small molecule inhibitors such as lapatinib target the kinase domain.
- Other names
- ERBB4Human Epidermal growth factor Receptor 4
02
Mechanism of action
Inhibition of tyrosine kinase activity by stabilizing inactive kinase conformation.
03
Biological functions
Development and maintenance of cardiovascular systemDevelopment and maintenance of nervous systemMammary gland developmentRegulation of gene transcriptionCell proliferationCell differentiationCell survivalSignal transduction
04
Disease associations
CancerCardiovascular diseaseDevelopmental disorders
05
Safety considerations
Complex role in cancer (tumor suppressor/promoter)Involvement in normal development
06
Interacting drugs
Lapatinib
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