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Receptor protein-tyrosine kinase Kit (c-Kit)
- Target
- c-Kit
- Molecular classification
- Receptor, Receptor tyrosine kinase, Type I transmembrane glycoprotein
01
Overview
Receptor protein-tyrosine kinase Kit, also known as CD117, c-Kit, or stem cell factor receptor (SCFR), is a transmembrane glycoprotein that functions as a receptor tyrosine kinase. This protein plays crucial roles in multiple cellular processes and is involved in various physiological and pathological conditions. It is a therapeutic target, particularly in oncology, and drugs like Imatinib target it.
- Other names
- CD117c-KitStem cell factor receptor (SCFR)Proto-oncogene c-KIT
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Cell survival and proliferationHematopoiesisGametogenesisMast cell developmentMelanogenesisGastrointestinal motilityStem cell maintenanceSignal transduction
04
Disease associations
Gastrointestinal stromal tumors (GISTs)PiebaldismHematological malignanciesAcute myelogenous leukemiaMastocytomasNasal T-cell lymphomasCancer
05
Safety considerations
Resistance to tyrosine kinase inhibitorsOff-target effects of inhibitors
06
Interacting drugs
STI-571 (Imatinib)
07
Biomarkers
KIT gene mutations (e.g., in GISTs)
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