Receptor-transporting protein 2 (RTP2)

Receptor-transporting protein 2 (RTP2) is a member of the zinc finger, 3CxxC-type protein family and acts as an accessory protein specifically facilitating the functional cell surface expression of mammalian olfactory receptors but not other G-protein-coupled receptors[1][4][11]. RTP2 enables olfactory receptor binding and is involved in protein insertion into the membrane, localizing primarily at the cell surface[1][10]. The gene is protein-coding, and although related diseases such as Bardet-Biedl syndrome 13 and familial glucocorticoid deficiency have been mentioned in association databases, direct causative or disease-driving roles are not well established[1]. RTP2 does not appear to be a common or validated drug target, nor is it directly implicated in major human diseases outside olfaction pathway variants[1][11].

Other names

receptor transporter protein 2Z3CXXC2MGC786653CxxC-type zinc finger protein 2receptor (chemosensory) transporter protein 2zinc finger, 3CxxC-type 2