Receptor-transporting protein 3 (RTP3)

Receptor-transporting protein 3 (RTP3) is a zinc finger transmembrane protein predicted to enable olfactory receptor binding activity and is involved in the detection of chemical stimuli for the sensory perception of bitter taste as well as in the targeting of proteins to the membrane[1][2][4]. It is primarily located in the cytoplasm. Recent genetic association studies have linked variants in RTP3 to bone geometry and skeletal fragility, suggesting a key role in bone structural stability[1]. There is also genomic proximity to genes involved in tumorigenesis (e.g., TMEM7), but RTP3 itself has not been directly established as a major therapeutic target, nor are specific drug interactions or safety concerns currently identified in the literature[1][2][4]. Key highlights: - Not a classical drug target (such as a receptor, enzyme, or transporter with known drugs) - Facilitates cell surface expression of certain bitter taste receptors (e.g., TAS2R16, TAS2R43)[4] - Functional variants are genetic risk factors in skeletal disorders but not established oncology targets[1]

Other names

Z3CXXC3LTM1TMEM7Transmembrane protein 73CxxC-type zinc finger protein 3zinc finger, 3CxxC-type 3