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Target intelligence / Profile preview
Receptor-type protein tyrosine phosphatase sigma (PTPσ)
- Target
- PTPσ
- Molecular classification
- Enzyme, Receptor, Protein Tyrosine Phosphatase, Type IIa receptor-type PTP
01
Overview
Receptor-type protein tyrosine phosphatase sigma (PTPσ) is a cell surface receptor with intrinsic phosphatase activity that regulates cellular signaling through dephosphorylation of tyrosine residues on target proteins. It plays critical roles in nervous system development, immune regulation, and other cellular processes, making it a potential therapeutic target for spinal cord injury, autoimmune diseases, and neuroregeneration.
- Other names
- R-PTP-sigmaRPTPSReceptor-type tyrosine-protein phosphatase S
02
Mechanism of action
Dephosphorylation of tyrosine residues on target proteins
03
Biological functions
SynaptogenesisAxon guidanceAxon regeneration inhibitionAxon repairImmune modulationSignal transduction
04
Disease associations
Spinal cord injuryAutoimmunityNeurodegenerative diseaseCentral nervous system injury
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