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Target intelligence / Profile preview
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
- Target
- FLT3
- Molecular classification
- Receptor, Receptor tyrosine kinase
01
Overview
FLT3 (Fms-like tyrosine kinase 3) is a class III receptor tyrosine kinase that plays a crucial role in hematopoiesis, cell survival, proliferation, and differentiation of hematopoietic cells. It is primarily expressed on hematopoietic stem/progenitor cells and is essential for normal development of stem cells and immune system function. Mutations in FLT3, particularly internal tandem duplications (ITD) and point mutations, are frequently found in acute myeloid leukemia (AML) and drive uncontrolled signaling, promoting leukemogenesis. As such, FLT3 has become an important therapeutic target for AML treatment.
- Other names
- CD135Fms-like tyrosine kinase 3FLK2fetal liver tyrosine kinase 2STK-1stem cell tyrosine kinase 1
02
Mechanism of action
Inhibition of FLT3 kinase activity, leading to decreased proliferation and survival of leukemic cells.
03
Biological functions
HematopoiesisCell survivalCell proliferationDifferentiation of hematopoietic cellsRegulation of stem cell developmentImmune system functionSignal transduction
04
Disease associations
Acute myeloid leukemia (AML)
05
Safety considerations
Resistance to FLT3 inhibitorsSide effects associated with kinase inhibitors
06
Interacting drugs
FLT3 inhibitors
07
Biomarkers
FLT3-ITD mutationsFLT3 point mutations in the activation loop
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