Receptor-type tyrosine-protein phosphatase alpha (PTPRA)

Receptor-type tyrosine-protein phosphatase alpha (PTPRA) is a cell-surface receptor-type protein tyrosine phosphatase enzyme that regulates key cellular processes such as cell growth, differentiation, and the cell cycle[1][2][4]. It consists of an extracellular domain, a single transmembrane segment, and two intracytoplasmic catalytic domains (D1—active, D2—regulatory)[1][4]. PTPRA is best known for dephosphorylating and activating Src family tyrosine kinases, implicating it in signal transduction mechanisms that control integrin signaling, cell adhesion, and proliferation[1][2][4]. Dysregulation of PTPRA function has been noted in oncogenic transformation, fibrosis, arthritis, and other diseases[2][4]. While not yet a major direct drug target, its structural domains and regulatory mechanisms suggest emerging interest in selective allosteric inhibition for therapeutic purposes[4].

Other names

Protein tyrosine phosphatase receptor type APTPAPTPRL2Protein-tyrosine phosphatase alphaR-PTP-alphaLRPHLPRHPTPARPTPAHEPTPreceptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptidePTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptidetyrosine phosphatase alphaRPTPα

Inhibition or allosteric modulation of phosphatase activity (potential, not clinically validated)